Section Navigation. Facebook Twitter LinkedIn Syndicate. Transmission Minus Related Pages. Related Links. Facebook Twitter LinkedIn Syndicate. Signs and Symptoms. Risk of Exposure. Links with this icon indicate that you are leaving the CDC website. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Where the infected rodent species prefers a field habitat, the risk of human infection is associated with agricultural work.
In areas where the rodent species habitat includes human homes or other buildings, infection occurs in domestic settings. LCMV causes aseptic non-bacterial meningitis. A number of arenaviruses cause hemorrhagic fever. The clinical spectrum of acquired human LCMV infection ranges from inapparent and asymptomatic to, in rare, instances, severely symptomatic, systemic, and fatal central nervous system CNS disease.
Additionally, pregnancy-related infection has been associated with congenital hydrocephalus, chorioretinitis and mental retardation. Typical LCMV infection in adults is a biphasic disease with fever, malaise, myalgias, anorexia, nausea, vomiting, pharyngitis, cough, and adenopathy followed by defervescence and a second phase of CNS disease.
However, CNS symptoms may appear without any prodrome or may never develop. Meningitis and meningoencephalitis are the most frequent neurologic manifestations of disease. Exposure to aerosols, bites or scratches involving animals or injuries from objects contaminated with body fluids from animals require immediate first aid and medical attention.
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