Contact Us Home. Inhibition mechanism Once HIV has entered the target host cell reverse transcription, initiated by the viral reverse transcriptase RT enzyme, occurs. Correlation between intracellular pharmacological activation of nucleoside analogues and HIV suppression in vitro P. Hoggard, S. Sales, S. Kewn, D. Sunderland, S. Khoo, C. Hart, D. Back Antivir. November ; ? Zapor, Kelly L. Cozza, Gary H.
Wynn, Glenn W. Wortmann, Scott C. Armstrong Psychosomatics December ; ? Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase Karen S.
Anderson Biochim. Acta July 18, ; ? Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity G. Moyle Clin Ther August ; ? Dermatologic complications associated with administration of 2? McNeely, R. Yarchoan, S. Broder, T. Lawley J. December ; ? Eron, S. Benoit, J. Jemsek, R. MacArthur, J. Santana, J. Quinn, D. Kuritzkes, M. Fallon, M. Rubin N. Dealing with side effects can be unpleasant, but stopping the medication may allow the virus to develop resistance.
This means that the medication may stop working as well to prevent the virus from replicating. The healthcare provider may be able to change the combination of drugs to decrease side effects. According to the NIH, the risk of some negative side effects may be higher if the person:. Also, alcoholism can increase the risk of liver damage. A person who has any of these risk factors should talk to their healthcare provider before taking NRTIs.
For these important drugs, newer versions cause fewer severe side effects than previous versions, but some side effects may still occur for any of these medications. If they have side effects from antiretroviral therapy , they can try these tips for reducing those side effects.
More importantly, they can talk to their healthcare provider, who can make suggestions or change their treatment plan to help relieve side effects.
More than 20 antiretroviral drugs are approved to treat HIV. These drugs are an important tool against the virus. Find out how advancements in treatments and our understanding of HIV are allowing people to live fuller lives. Also view lists of FDA-approved drugs. Today, medications are available to help extend the lives of those living with HIV.
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